Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs
Yao Ke, Ben-Zheng Li, Fulun Li, Resmi K. Ravindran, Donna Wang, Suyan Wang, Samuel T. Hwang, Scott Irwin Simon, Sean R. Collins, Christian D. Young, Xiao-Jing Wang
This study shows that Smad7-based biologic treatment accelerates diabetic wound healing in mice and pigs by targeting keratinocytes and neutrophils, reducing inflammation and promoting tissue repair.
Nature Communications · Mar 26, 2026Peer-reviewedImmunology