Sean R. Collins

SHROOM3 promotes leading-edge protrusion stability and Wnt/planar cell polarity-mediated migration in breast cancer cells

This study identifies SHROOM3 as a regulator of protrusion dynamics and Wnt/PCP-mediated migration in breast cancer cells, showing its role in stabilizing protrusions and coordinating ROCK1 localization.

SHIP1 partitions between cortical oscillations and membrane puncta to regulate neutrophil chemotaxis

This study identifies two SHIP1 localization modes during neutrophil chemotaxis, regulated by FBP17 and Nck1, and shows that the C-terminal domain is essential for proper chemotaxis.

Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs

This study shows that Smad7-based biologic treatment accelerates diabetic wound healing in mice and pigs by targeting keratinocytes and neutrophils, reducing inflammation and promoting tissue repair.

Parallel CRISPR screens reveal pathways controlling the cell surface levels of the attractant receptor FPR1

This study identifies regulators of FPR1 surface expression and internalization using CRISPR screens, revealing multiple pathways and previously unknown factors involved in receptor trafficking.

Delineation of the SUMO-Modified Proteome Reveals Regulatory Functions Throughout Meiosis

The paper identifies 2747 SUMO modification sites in budding yeast meiosis, revealing SUMO's role in chromosome organization and recombination.

A map of gene expression in neutrophil-like cell lines

The paper compares gene expression in HL-60 and PLB-985 cell lines before and after differentiation to primary neutrophils, finds DMSO-based protocols are effective, and creates a gene expression database.