Subcellular localization of mutant P23H rhodopsin in an RFP fusion knockin mouse model of retinitis pigmentosa
Michael A. Robichaux, Vy Nguyen, Fung Chan, Lavanya Kailasam, Feng He, John H. Wilson, Theodore G. Wensel
This study creates a mouse model of retinitis pigmentosa with a P23H-Rho-RFP fusion to study subcellular localization and disease progression, finding slow retinal degeneration and ER accumulation of mutant protein.
Disease Models & Mechanisms · Mar 11, 2022Peer-reviewedNeuroscience