Michael A. Robichaux

This study identifies a novel ciliary rootlet defect in Atf6-/- mouse photoreceptors, linking ATF6 function to cytoskeletal integrity and photoreceptor degeneration.

This study uses super-resolution microscopy to show that Rab6a regulates rhodopsin trafficking from the trans-Golgi in mammalian rod photoreceptors, with implications for retinal health.

This study investigates the role of CEP290 in photoreceptor ciliary structure and outer segment formation in mice, finding defects in ciliary necklace and Y-links, and altered distribution of transition zone proteins.

This study investigates how mislocalized P23H rhodopsin affects synaptic protein levels in rod photoreceptors using mouse models and proteomics.

This study creates a mouse model of retinitis pigmentosa with a P23H-Rho-RFP fusion to study subcellular localization and disease progression, finding slow retinal degeneration and ER accumulation of mutant protein.

RAIN-STORM enables rapid 3D nanoscale imaging of multiple molecular targets in tissue, revealing detailed structures in human samples.