NeuroscienceDisease Models & MechanismsPeer-reviewed
Subcellular localization of mutant P23H rhodopsin in an RFP fusion knockin mouse model of retinitis pigmentosa
Michael A. Robichaux, Vy Nguyen, Fung Chan…·Theodore G. Wensel
This study creates a mouse model of retinitis pigmentosa with a P23H-Rho-RFP fusion to study subcellular localization and disease progression, finding slow retinal degeneration and ER accumulation of mutant protein.