G. An

The Wound Environment Agent-based Model (WEABM): a digital twin platform for characterization and complex therapeutic discovery for volumetric muscle loss

This paper develops a digital twin platform, WEABM, to model VML healing and discover therapeutic strategies through simulation-based reinforcement learning.

Microsporidia Ser/Thr Protein Phosphatase PP1 Targets DCs MAPK Pathway and Impairs Immune Functions

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

Preparing for the next COVID: Deep Reinforcement Learning trained Artificial Intelligence discovery of multi-modal immunomodulatory control of systemic inflammation in the absence of effective anti-microbials

This paper uses deep reinforcement learning to discover immunomodulatory strategies for controlling systemic inflammation in the absence of effective anti-microbials, reducing mortality from 85% to 10.4% in simulations.

A potent SARS-CoV-2 neutralizing antibody recognizing a conserved epitope with broad mutant variant and SARS-CoV activity.

This paper identifies a SARS-CoV-2 neutralizing antibody, ABP-310, that is effective against multiple variants including Omicron and SARS-CoV, suggesting broad therapeutic potential.

Quantifying the size and healing of volumetric muscle wounds using 3D Slicer on CT scans in a canine model

The paper presents a method to quantify volumetric muscle wound size and healing using 3D Slicer on CT scans in a canine model.

Comparative computational modeling of the bat and human immune response to viral infection with the Comparative Biology Immune Agent Based Model

This study develops a computational model to compare bat and human immune responses to viral infection, highlighting differences in inflammasome activity and Type 1 Interferon dynamics that contribute to viral tolerance.

The Rice propiconazole resistant 1-D mutant, with activated expression of a DPb transcription factor gene, exhibits increased seed yields

This paper identifies a rice mutant with increased seed yields due to activated expression of a DPb-like transcription factor gene, suggesting its role in BR-mediated cell division.

The Cellular Immunity Agent Based Model (CIABM): Replicating the cellular immune response to viral respiratory infection

The paper introduces CIABM, an agent-based model of the cellular immune response to viral infections, validated against clinical data on influenza patients.