G. Cheng

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

qMAP Enabled Microanatomical Mapping of Human Skin Aging

This study introduces qMAP, a deep learning-based workflow for microanatomical mapping of human skin, identifying 10 core processes strongly associated with aging and achieving age prediction accuracy comparable to epigenetic clocks.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

Distinct transcriptional profiles of maternal and fetal placental macrophages at term are associated with gravidity

The paper compares transcriptional profiles of maternal and fetal placental macrophages in term pregnancies, finding distinct gene expression patterns linked to gravidity.

Microsporidia Ser/Thr Protein Phosphatase PP1 Targets DCs MAPK Pathway and Impairs Immune Functions

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

This study identifies ferroptosis as a mechanism by which imetelstat induces therapeutic effects in AML, showing that targeting fatty acid metabolism enhances its efficacy.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

The specific roles of renal macrophages in monitoring and clearing off intratubular particles

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant

This paper develops a ferritin-based nanoparticle vaccine targeting the SARS-CoV-2 Omicron variant, showing enhanced immunogenicity compared to a non-nanoparticle version.

The evolution of fluoroquinolone resistance in Salmonella under exposure to sub-inhibitory concentration of enrofloxacin

This study examines how Salmonella develops resistance to enrofloxacin under varying sub-inhibitory concentrations, identifying gene expression changes and mutations involved in resistance.

A recombinant receptor-binding domain in trimeric form generates completely protective immunity against SARS-CoV-2 infection in nonhuman primates

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

An Essential Role of UBXN3B in B Lymphopoiesis

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

Precise Localization and Dynamic Distribution of Japanese Encephalitis Virus in theBrain Nuclei of Infected Mice

This study tracks the dynamic localization of Japanese encephalitis virus (JEV) in mouse brain nuclei over time, revealing its progression from thalamus and medulla oblongata to widespread distribution in the central nervous system.

Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

Mutations, Recombination and Insertion in the Evolution of 2019-nCoV

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

Chiroptical Kirigami Modulators for Terahertz Circular Dichroism Spectroscopy of Biomaterials

This paper introduces tunable optical elements for terahertz circular dichroism spectroscopy, enabling dynamic polarization modulation of THz radiation through mechanical strain.

Sacral agenesis: A pilot whole exome sequencing and copy number study

This study uses whole exome sequencing and copy number analysis to identify genetic variants in four CRS trios, finding de novo and inherited mutations in candidate genes and CNVs overlapping with previously reported deletions.