Liver-specification of human iPSC-derived endothelial cells transplanted into mouse liver
K. K. Yap, J. Schroeder, Y.-W. Gerrand, A. Kong, A. M. Fox, B. Knowles, S. W. Banting, A. K. Elefanty, E. G. Stanley, G. C. Yeoh, G. P. Lockwood, V. C. Cogger, W. A. Morrison, J. M. Polo, G. M. Mitchell
This study transplants human iPSC-derived endothelial cells into mice to generate LSEC-like cells, identifies key transcription factors and markers for LSEC specification, and provides a model for studying liver endothelial development.
bioRxiv · Jun 28, 2023Cell Biology