Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase
M. C. Johnson, G. Can, M. Santos, D. Alexander, P. Zegerman
This study shows that the S-phase checkpoint, via Rad53 kinase, inhibits replication initiation factors beyond S-phase, preventing re-replication and inappropriate gene amplification in G2/M and G1 phases.
bioRxiv · Sep 30, 2020Cell Biology