M. Santos

Tittle: An integrated analysis of the structural changes and gene expression of spleen in human visceral leishmaniasis with and without HIV coinfection

This study compares structural and gene expression changes in spleens of visceral leishmaniasis patients with and without HIV coinfection, identifying key pathways and gene associations linked to spleen disorganization.

Non-viral CRISPR/Cas9 Mutagenesis for Streamlined Generation of Mouse Lung Cancer Models

This paper introduces a non-viral CRISPR/Cas9 method using cationic polymers to generate mouse lung cancer models by inactivating tumor suppressor genes, enabling rapid and flexible hypothesis testing.

RNA polymerase III is involved in regulating Plasmodium falciparum virulence

The paper shows RNA polymerase III regulates Plasmodium falciparum virulence by controlling cytoadhesion and responding to external stimuli in asymptomatic infections.

From Bayes to Darwin: evolutionary search as an exaptation from sampling-based Bayesian inference

The paper demonstrates how Darwinian evolution can emerge from Bayesian inference through collective selection in high-dimensional environments.

tRNASer overexpression induces adaptive mutations in NSCLC tumors

This study shows that overexpressing tRNASer in NSCLC tumors increases mutation burden and generates variants that promote proliferation and therapy resistance.

Direct Comparison of Lysine vs. Site-specific Protein Surface Immobilization in Single-molecule Mechanical Assays

This study compares lysine-based and site-specific protein immobilization methods in single-molecule force spectroscopy, finding that lysine-based methods degrade signal quality and alter unfolding pathway classification.

A la carte, Streptococcus pneumoniae capsular typing: using MALDI-TOF mass spectrometry and machine learning algorithms as complementary tools for the determination of PCV13 serotypes and the most prevalent NON PCV13 serotypes according to Argentina's epidemiology.

This paper evaluates MALDI-TOF MS combined with machine learning for serotyping S. pneumoniae isolates in Argentina, achieving moderate accuracy in identifying PCV13 and non-PCV13 serotypes.

Biogeographical history shapes evolution of reproduction in a global warming scenario

This study shows that northern Drosophila subobscura populations improve performance at higher temperatures over generations, while southern populations decline, suggesting limited evolutionary potential under global warming.

Biosynthesis and apoplast accumulation of the apocarotenoid pigment azafrin in parasitizing roots of Escobedia grandiflora

This study identifies azafrin as the orange pigment in Escobedia grandiflora roots, reveals its biosynthesis via a CCD enzyme, and suggests its role in parasitization.

Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis

This study uses genome editing in Capsaspora owczarzaki to show that the Hippo pathway ortholog coYki regulates cytoskeletal dynamics and multicellular shape, suggesting an ancestral role in multicellular morphogenesis.

Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 promotes tumour growth

The paper shows that discontinuous TGFβ1 exposure induces EMT/MET transitions in EpH4 cells, leading to RE-cells with molecular and functional heterogeneity that promotes tumour growth.

LysM receptors in Coffea arabica: identification, characterization, and gene expression in response to Hemileia vastatrix

This study identifies and characterizes LysM receptor-like sequences in Coffea arabica and shows their expression is induced by Hemileia vastatrix inoculation.

Soluble ECM promotes organotypic formation in lung alveolar model

This study shows that adding soluble ECM to suspension culture enables the formation of organotypic lung structures from stable cell lines, including lumen-like airspaces and vasculature, and models lung fibrosis with drug testing capabilities.

No evidence for short-term evolutionary response to a warming environment in Drosophila

This study shows no significant evolutionary adaptation to warming in Drosophila after nine generations, with historical background and trait-specific effects influencing thermal responses.

Vertical stratification of environmental DNA in the open ocean captures ecological patterns and behavior of deep-sea fishes

The paper analyzes eDNA from vertical ocean profiles to reveal day-night patterns in deep-sea fish distribution, linking eDNA data to migratory behavior and species movement.

Filamentation in Candida albicans is modulated by adaptive translation of farnesol signalling genes

This study shows that atypical CUG codon translation in Candida albicans modulates filamentation by altering farnesol production and Nrg1 repressor degradation.

Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

This study shows that the S-phase checkpoint, via Rad53 kinase, inhibits replication initiation factors beyond S-phase, preventing re-replication and inappropriate gene amplification in G2/M and G1 phases.

High developmental temperature leads to low reproduction despite adult temperature

This study examines how developmental temperature affects reproductive performance in Drosophila subobscura, finding that high developmental temperatures reduce reproduction regardless of adult temperature.

Phenotypes to remember: Evolutionary developmental memory capacity and robustness

The paper investigates how developmental memories of past phenotypes form, persist, and are robust in genetic and neural networks, using analogies between these systems.

EXPRESSION OF Mycobacterium tuberculosis RpsA IN Mycobacterium smegmatis INCREASES SUSCEPTIBILITY TO PYRAZINAMIDE

This study shows that expressing Mycobacterium tuberculosis RpsA in Mycobacterium smegmatis reduces its susceptibility to pyrazinamide.

Marine water environmental DNA metabarcoding provides a comprehensive fish diversity assessment and reveals spatial patterns in a large oceanic area

This study uses environmental DNA metabarcoding to assess marine fish diversity in a large oceanic area, finding it detects more species than trawling and aligns with ecological knowledge.

Evolution of linkage and genome expansion in protocells

This study shows that chromosomes evolve in protocells despite replicative disadvantages, leading to increased genome size and multigene families due to reduced assortment load.

How phenotypic convergence arises in experimental evolution

This study examines whether initially differentiated Drosophila subobscura populations converge to similar adaptive states after 60 generations in a common environment, finding persistent differentiation despite convergence patterns.