A simple bypass assay for DNA polymerases shows hypermutating variants associated with cancer show mechanistic differences in vitro
G. Crevel, S. Kearsey, S. Cotterill
The paper develops a bypass assay to study DNA polymerase misincorporation and finds hypermutating variants P286R and V411L show distinct in vitro misincorporation patterns.
bioRxiv · Jan 10, 2022 · PreprintBiochemistry