Author

S. Kearsey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:whole-genome sequencing· 1 Organism:yeast· 1

Frequent Co-Authors

S. Cotterill· 2 shared C. Palles· 1 shared C.-C. Pai· 1 shared E. Heitzer· 1 shared E. Vazquez· 1 shared G. Crevel· 1 shared I. Soriano· 1 shared I. Tomlinson· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

S. Cotterill

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2 papers

Recent·Most cited

A simple bypass assay for DNA polymerases shows hypermutating variants associated with cancer show mechanistic differences in vitro

G. Crevel, S. Kearsey, S. Cotterill

The paper develops a bypass assay to study DNA polymerase misincorporation and finds hypermutating variants P286R and V411L show distinct in vitro misincorporation patterns.

bioRxiv · Jan 10, 2022 · PreprintBiochemistry

Expression of the cancer-associated DNA polymerase ϵ P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

I. Soriano, E. Vazquez, N. de Leon, S. Betrand, E. Heitzer, S. Toumazou, C. Palles, C.-C. Pai, T. Humphrey, I. Tomlinson, S. Cotterill, S. Kearsey

This paper models the POLE-P286R mutation in fission yeast, showing it causes hypermutation, DNA replication defects, and dependence on translesion synthesis polymerases.

bioRxiv · Apr 6, 2021Cancer Biology