Cytotoxic activity of CD4 T Cells during the early stage of autoimmune neuroinflammation
A. S. Farias, F. Pradella, V. O. Boldrini, A. M. Marques, G. D. Morais, C. Francelin, R. S. Cocenza, V. C. Lima, M. Bonora-Jr, N. S. Brunetti, B. B. Campos, E. S. M. Fonseca, M. Rocha-Parise, C. R. V. Stella, A. Damasceno, , L. M. B. Santos
This study shows that pathogenic CD4+ T cells exhibit cytotoxic activity in early autoimmune neuroinflammation, contributing to myelin lesions and being enhanced in RRMS patients.
bioRxiv · Mar 10, 2020 · PreprintImmunology