Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells
G. Bagchi, J. P. Singh, M. Dagar, G. Dagar, S. Rawal, R. D. Sharma, R. K. Tyagi
This study shows that GPR56 activation by androgens enhances AR signaling through Rho and cAMP/PKA pathways, and its expression is higher in prostate tumors, suggesting it as a therapeutic target.
bioRxiv · Nov 21, 2019Cancer Biology