Author

G. De Las Heras

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Biophysics· 1

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Research Focus:cell signaling & trafficking· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

B. Larijani· 1 shared J. Dessolin· 1 shared J. Requejo-Isidro· 1 shared R. Bailly· 1 shared V. Calleja· 1 shared

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2019-2019 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

B. Larijani

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1 paper

Recent·Most cited

BiophysicsbioRxivMar 3, 2019

A Complex Interplay of Anionic Phospholipid Binding Regulates 3-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation

G. De Las Heras, V. Calleja, R. Bailly…·B. Larijani

This study reveals how anionic phospholipids regulate PDK1 homodimer activation through conformational dynamics, showing phosphatidylserine maintains inactivity and dysregulation leads to constitutive activation in carcinomas.

DOI 10.1038/s41598-019-50742-8

proteomicsmicroscopy & imaging analysis

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