Chronic circadian disruption modulates breast cancer cell stemness and their immune microenvironment to drive metastasis in mice
E. Hadadi, W. Taylor, X. Li, Y. Aslan, M. Vilotte, J. Riviere, G. Duvallet, C. Auriau, S. Dulong, I. Raymond Letron, S. Provot, A. Bennaceur-Griscelli, H. Acloque
This study shows chronic circadian disruption in mice increases breast cancer metastasis by enhancing stemness and creating an immunosuppressive microenvironment, which can be reversed by a CXCR2 inhibitor.
bioRxiv · Sep 26, 2019Cancer Biology