A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance
G. Giacoletti, T. Price, L. V. B. Hoelz, A. Shremo Msdi, K. Vazquez-Falto, T. V. Amorim Fernandes, V. Santos de Pontes, H. Wang, N. Boechat, A. Nornoo, T. Brust
This study shows that ST034307, a selective AC1 inhibitor, relieves pain in mouse models without causing tolerance.
bioRxiv · Jun 23, 2021Pharmacology & Toxicology