C/EBPβ-LIP dually activates glycolysis and the malate aspartate shuttle to maintain NADH/NAD+ homeostasis
T. Ackermann, H. R. Zuidhof, G. Kortman, M. G. S. Rutten, M. J. C. Broekhuis, M. A. Zaini, G. Hartleben, C. F. Calkhoven
This study shows that C/EBPβ-LIP activates both glycolysis and the malate-aspartate shuttle to maintain NADH/NAD+ homeostasis, and inhibiting both could be a strategy for cancer treatment.
bioRxiv · Oct 9, 2020 · PreprintCancer Biology