Author

H. R. Zuidhof

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

C. F. Calkhoven· 2 shared G. Kortman· 2 shared C. Müller· 1 shared E. Stepanova· 1 shared F. Loayza-Puch· 1 shared G. Hartleben· 1 shared M. A. Zaini· 1 shared M. G. S. Rutten· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

C. F. Calkhoven

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2 papers

Recent·Most cited

Oncogenic functions of the m6A demethylase FTO in breast cancer cells involving translational upregulation of C/EBPβ-LIP

H. R. Zuidhof, C. Müller, G. Kortman, R. Wardenaar, E. Stepanova, F. Loayza-Puch, C. F. Calkhoven

This study shows FTO promotes oncogenic functions in TNBC by regulating C/EBPβ-LIP translation, which drives EMT and metastasis.

bioRxiv · Sep 21, 2023 · PreprintCancer Biology

C/EBPβ-LIP dually activates glycolysis and the malate aspartate shuttle to maintain NADH/NAD+ homeostasis

T. Ackermann, H. R. Zuidhof, G. Kortman, M. G. S. Rutten, M. J. C. Broekhuis, M. A. Zaini, G. Hartleben, C. F. Calkhoven

This study shows that C/EBPβ-LIP activates both glycolysis and the malate-aspartate shuttle to maintain NADH/NAD+ homeostasis, and inhibiting both could be a strategy for cancer treatment.

bioRxiv · Oct 9, 2020 · PreprintCancer Biology