Cyclic nucleotide-induced superhelical structure activates a bacterial TIR immune effector
G. Hogrel, A. Guild, S. Graham, H. Rickman, S. Grushow, Q. Bertrand, L. Spagnolo, M. F. White
The paper shows a bacterial TIR-SAVED effector forms a superhelical structure upon binding cyclic tri-adenylate, enabling NAD+ degradation as part of an anti-viral defense mechanism.
bioRxiv · May 4, 2022Biochemistry