Author

L. Spagnolo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. Graham· 2 shared A. Guild· 1 shared C. Arkinson· 1 shared D. Kompaniiets· 1 shared g. cannone· 1 shared G. Hogrel· 1 shared H. Rickman· 1 shared H. Walden· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

S. Graham

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure of the Saccharolobus solfataricus type III-D CRISPR effector

L. Spagnolo, M. White, g. cannone, D. Kompaniiets, S. Graham

The paper reports the cryo-EM structure of the S. solfataricus Type III-D CRISPR effector complex, revealing its organization and RNA-binding mechanism.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

Cyclic nucleotide-induced superhelical structure activates a bacterial TIR immune effector

G. Hogrel, A. Guild, S. Graham, H. Rickman, S. Grushow, Q. Bertrand, L. Spagnolo, M. F. White

The paper shows a bacterial TIR-SAVED effector forms a superhelical structure upon binding cyclic tri-adenylate, enabling NAD+ degradation as part of an anti-viral defense mechanism.

bioRxiv · May 4, 2022Biochemistry

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

H. Walden, M. L. Rennie, K. Lemonidis, C. Arkinson, V. K. Chaugule, M. Clarke, J. Streetley, L. Spagnolo

This study identifies how ubiquitination of FANCI and FANCD2 stabilizes the ID2 complex on DNA, enhancing its affinity for double-stranded DNA and protecting ubiquitin from deubiquitination.

bioRxiv · Feb 3, 2020Biochemistry