Author

G. Interlandi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 3 Organism:human· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

E. N. Pederson· 1 shared R. Tsai· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

2 top collaborators · 0 mutual co-author links

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1 shared paperBiochemistry

E. N. Pederson

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3 papers

Recent·Most cited

Exploring ligands that target von Willebrand factor selectively under oxidizing conditions through docking and molecular dynamics simulations

This paper identifies a ligand that selectively binds to the A1A2 interface of von Willebrand factor under oxidizing conditions, potentially restoring auto-inhibition during inflammation.

bioRxiv · Mar 22, 2024Biophysics

Oxidation shuts down an auto-inhibitory mechanism of von Willebrand factor

R. Tsai, G. Interlandi

This study investigates how methionine oxidation in von Willebrand factor (VWF) removes an auto-inhibitory mechanism, revealing that oxidation destabilizes the A1-A2 domain interface, unmasking the GpIb-binding site.

bioRxiv · Jan 18, 2021Biophysics

Oxidation-induced destabilization of the fibrinogen α-domain dimer investigated by molecular dynamics simulations

E. N. Pederson, G. Interlandi

This study uses molecular dynamics simulations to investigate how oxidation of Met476 in the fibrinogen C domain affects dimer formation and lateral aggregation of protofibrils.

bioRxiv · Aug 9, 2019Biochemistry