Author

G. K. Popescu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

G. J. Iacobucci· 3 shared H. Wen· 2 shared W. Zheng· 2 shared B. Liu· 1 shared B. Sincox· 1 shared E. M. Kasperek· 1 shared J. A. Abbott· 1 shared J. M. Myers· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

G. J. Iacobucci

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3 papers

Recent·Most cited

Complex functional phenotypes of NMDA receptor disease variants

G. J. Iacobucci, B. Liu, H. Wen, B. Sincox, W. Zheng, G. K. Popescu

This study investigates how specific NMDA receptor variants affect receptor function through molecular dynamics and electrophysiology, revealing that altered interactions at P552 and F652 lead to complex functional deficits.

bioRxiv · Jul 1, 2022Biophysics

Contributions by N-terminal Domains to NMDA Receptor Currents

S. A. Amico-Ruvio, M. A. Paganelli, J. A. Abbott, J. M. Myers, E. M. Kasperek, G. J. Iacobucci, G. K. Popescu

This study shows that NMDA receptor activation events do not require the N-terminal domains, as truncated receptors maintain core gating mechanisms and isoform-specific kinetics.

bioRxiv · Aug 21, 2020 · PreprintBiophysics

Cross-subunit Interactions that Stabilize Open States Mediate Gating in NMDA Receptors

G. J. Iacobucci, H. Wen, M. B. Helou, W. Zheng, G. K. Popescu

The paper identifies a cross-subunit interaction in NMDA receptors that stabilizes open states and slows current decay, linking it to pathogenic variants.

bioRxiv · Jun 8, 2020Biophysics