Elucidation of the signatures of proteasome-catalysed peptide splicing
W. Paes, G. Leonov, T. Partridge, A. Nicastri, N. Ternette, P. Borrow
This study defines the biochemical constraints of proteasome-catalysed cis-splicing reactions through in vitro experiments and mass-spectrometry-based sequencing, revealing sequence- and size-dependent splicing signatures.
bioRxiv · Apr 5, 2020 · PreprintImmunology