Author

T. Partridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

P. Borrow· 4 shared N. Ternette· 2 shared A. Bridgeman· 1 shared A. Chiarenza· 1 shared A. Damianou· 1 shared A. Nicastri· 1 shared A. Pinto-Fernandez· 1 shared A. Townsend· 1 shared

Activity by Year

2020-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersImmunology

P. Borrow

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

R. Parker, T. Partridge, C. Wormald, R. Kawahara, V. Stalls, M. Aggelakopoulou, J. Parker, R. Powell Doherty, Y. Ariosa-Morejon, E. Lee, K. Saunders, B. F. Haynes, P. Acharya, M. Thaysen-Andersen, P. Borrow, N. Ternette

The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.

bioRxiv · Aug 19, 2020Immunology

Elucidation of the signatures of proteasome-catalysed peptide splicing

W. Paes, G. Leonov, T. Partridge, A. Nicastri, N. Ternette, P. Borrow

This study defines the biochemical constraints of proteasome-catalysed cis-splicing reactions through in vitro experiments and mass-spectrometry-based sequencing, revealing sequence- and size-dependent splicing signatures.

bioRxiv · Apr 5, 2020 · PreprintImmunology

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

A. Pinto-Fernandez, M. Salio, T. Partridge, J. Chen, G. Vere, H. Greenwood, C. S. Olie, A. Damianou, H. C. Scott, H. J. Pegg, A. Chiarenza, L. Diaz-Saez, P. Smith, C. Gonzalez-Lopez, B. Patel, , B. M. Kessler

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.

bioRxiv · Mar 31, 2020 · PreprintCancer Biology

cGAMP loading enhances the immunogenicity of VLP vaccines

L. Chauveau, A. Bridgeman, T. K. Tan, R. Beveridge, J. Frost, I. Pedroza-Pacheco, T. Partridge, P. Borrow, H. Drakesmith, A. Townsend, J. Rehwinkel

This study shows that incorporating cGAMP into virus-like particles (VLPs) enhances their immunogenicity, leading to stronger T cell responses and antibody titres against HIV and influenza viruses.

bioRxiv · Jan 3, 2020 · PreprintImmunology