Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
N. Ait-Bouziad, A. Chiki, G. Limorenko, S. Xiao, D. Eliezer, H. Lashuel
This study shows that phosphorylation of tyrosine 310 in Tau reduces its aggregation and microtubule/lipid-binding properties by decreasing β-sheet propensity in the PHF6 domain.
bioRxiv · Jan 6, 2020Biochemistry