S. Xiao

Premature thymic involution in young Foxn1lacz mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence

SLC17 transporters mediate renal excretion of Lac-Phe in mice and humans

This study identifies SLC17A1 and SLC17A3 as key transporters for Lac-Phe excretion in urine, showing genetic and functional associations in mice and humans.

Predicting Functional Conformational Ensembles and Binding Mechanisms of Convergent Evolution for SARS-CoV-2 Spike Omicron Variants Using AlphaFold2 Sequence Scanning Adaptations and Molecular Dynamics Simulations

This study uses AlphaFold2 and molecular dynamics to predict conformational ensembles and binding mechanisms of SARS-CoV-2 Omicron variants, showing agreement with experimental data.

A PTER-dependent pathway of taurine metabolism linked to energy balance

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

Ovarian disrupting effects and mechanisms of long- and short-chain per- and polyfluoroalkyl substances in mice

This study investigates the effects of long- and short-chain PFAS on ovarian function in mice, finding that long-chain PFAS disrupt follicle maturation and ovulation via PPARγ activation.

Interpretable Atomistic Prediction and Functional Analysis of Conformational Ensembles and Allosteric States in Protein Kinases Using AlphaFold2 Adaptation with Randomized Sequence Scanning and Local Frustration Profiling

This study adapts AlphaFold2 to predict conformational ensembles and allosteric states of ABL kinase using sequence scanning and frustration profiling, revealing limitations in detecting low-populated inactive states.

Genomic insights into photosymbiotic evolution in Tridacna squamosa

This study presents the first complete genome of Tridacna squamosa and integrates multi-omics data to uncover molecular mechanisms underlying photosymbiosis with dinoflagellates.

Microsecond Molecular Dynamics Simulations and Markov State Models of Mutation-Induced Allosteric Mechanisms for the Light-Oxygen-Voltage 2 Protein : Revealing Structural Basis of Signal Transmission Induced by Photoactivation of the Light Protein State

This study uses molecular dynamics simulations and Markov state models to analyze mutation-induced allostery in AsLOV2, identifying key β-sheet interactions critical for signal transmission during photoactivation.

AlphaFold2-Enabled Atomistic Modeling of Epistatic Binding Mechanisms for the SARS-CoV-2 Spike Omicron XBB.1.5, EG.5 and FLip Variants: Convergent Evolution Hotspots Cooperate to Control Stability and Conformational Adaptability in Balancing ACE2 Binding and Antibody Resistance

This study uses AlphaFold2 and molecular simulations to analyze how mutations in SARS-CoV-2 Spike protein variants balance ACE2 binding and antibody resistance through epistatic interactions.

VviWRKY10 and VviWRKY30 co-regulate powdery mildew resistance through modulating SA and ET-based defenses in grapevine

This study shows VviWRKY10 and VviWRKY30 regulate powdery mildew resistance in grapevine by modulating SA and ET defenses, with mutual transcriptional inhibition between the two genes.

Accurate Characterization of Conformational Ensembles and Binding Mechanisms of the SARS-CoV-2 Omicron BA.2 and BA.2.86 Spike Protein with the Host Receptor and Distinct Classes of Antibodies Using AlphaFold2-Augmented Integrative Computational Modeling

This study uses AlphaFold2 and molecular dynamics to analyze the structure, dynamics, and binding of SARS-CoV-2 Omicron BA.2.86 spike protein with ACE2 and antibodies, revealing key mutations that enhance immune evasion and ACE2 binding.

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves

This study investigates the interplay between formins and Arp2/3 complex in cortical actin wave dynamics, revealing both cooperation and antagonism regulated by Cdc42.

Examining Functional Linkages Between Conformational Dynamics, Protein Stability and Evolution of Cryptic Binding Pockets in the SARS-CoV-2 Omicron Spike Complexes with the ACE2 Host Receptor: Recombinant Omicron Variants Mediate Variability of Conserved Allosteric Sites and Binding Epitopes

This study uses simulations and analysis of SARS-CoV-2 Omicron variants to examine conformational dynamics, protein stability, and evolution of cryptic binding pockets in the spike complex with ACE2.

Soil intake modifies the gut microbiota and alleviates ovalbumin-induced mice asthma inflammation

The paper shows that sterilized soil intake reduces asthma inflammation in mice by altering gut microbiota and shifting immune responses toward Th1.

Markov State Models and Perturbation-Based Approaches Reveal Distinct Dynamic Signatures and Hidden Allosteric Pockets in the Emerging SARS-Cov-2 Spike Omicron Variants Complexes with the Host Receptor: The Interplay of Dynamics and Convergent Evolution Modulates Allostery and Functional Mechanisms

This study uses computational methods to analyze conformational dynamics and allosteric pockets in SARS-CoV-2 Omicron variants bound to ACE2, revealing how convergent mutations influence immune escape and functional mechanisms.

Probing Conformational Landscapes of Binding and Allostery in the SARS-CoV-2 Omicron Variant Complexes Using Microsecond Atomistic Simulations and Perturbation-Based Profiling Approaches: Hidden Role of Omicron Mutations as Modulators of Allosteric Signaling and Epistatic Relationships

This study uses simulations and profiling to analyze how Omicron mutations affect binding, allostery, and thermodynamics in SARS-CoV-2 complexes with ACE2.

A parasitoid serpin gene that disrupts host immunity shows adaptive evolution of alternative splicing

The paper studies the evolution of alternative splicing and gene duplication in a parasitoid serpin gene, finding they jointly contribute to protein diversity and show divergent evolutionary patterns.

Nanopore sequencing for the 17 modification types in 36 locations in E. coli ribosomal RNA enables monitoring of stress-dependent changes

This study uses nanopore sequencing to detect 17 RNA modifications in E. coli rRNA and shows how metabolic and cold-shock stress affect these modifications.

High-throughput deep tissue two-photon microscopy at kilohertz frame rates

This paper presents a method to enable kilohertz frame rates in two-photon microscopy for deep tissue imaging, demonstrating its application in mouse brain neurovascular dynamics.

Pathogen effector-associated nuclear-localization of RPW8.2 amplifies its expression to boost immunity in Arabidopsis

The paper identifies a fungal effector that enhances RPW8.2 nuclear localization and transcription, boosting immunity in Arabidopsis against powdery mildew.

Bi-Phasic Quasistatic Brain Communication for Fully Untethered Connected Brain Implants

This paper introduces BP-QBC, a new wireless communication method for brain implants that achieves low end-to-end channel loss and high data rates using electro-quasistatic signaling.

Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model

This study shows that aucubin promotes functional recovery after spinal cord injury by reducing inflammation and neuronal apoptosis through the TLR4/NF-κB pathway and mitochondrial protection.

GJA1-20k, an internally translated isoform of Connexin 43, is an actin capping protein

This study identifies GJA1-20k as an actin capping protein that regulates mitochondrial fission and protects against ischemia-reperfusion injury.

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Adjunctive inhibition of the integrated stress response pathway accelerates bacterial clearance in a mouse model of tuberculosis

This study shows that inhibiting the Integrated Stress Response (ISR) pathway alongside standard TB antibiotics reduces bacterial loads and accelerates sterilization in a mouse model of tuberculosis.

Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

The paper shows that spatially restricted protease activity in lymph node follicles preserves antigen integrity, leading to stronger GC responses when antigens are targeted to follicular dendritic cells.

DEAD-box RNA helicase 18 disrupts IRF3-binding to the interferon-β promoter

This study identifies DDX18 as a negative regulator of IRF3 binding to the IFN-β promoter, suppressing type I IFN production during viral infection.

Oxalic acid binds to gustatory receptor Gr23a and inhibits feeding in the brown planthopper

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

Dynamic surveillance of mosquitoes and their viromes in Wuhan during 2020.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.