Herpes Simplex Virus type 1 Inflammasome Activation in Human Macrophages is Dependent on NLRP3, ASC, and Caspase-1
A. H. Karaba, A. Figueroa, G. Massaccesi, S. Botto, V. R. DeFilippis, A. Cox
This study shows HSV-1 activates inflammasomes in human macrophages via NLRP3, ASC, and caspase-1, but not AIM2 or IFI16, and the virus inhibits inflammasome activation through an NLRP3-specific mechanism.
PLOS ONE · Feb 26, 2020Peer-reviewedMicrobiology