Author

V. R. DeFilippis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Assay:metagenomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

S. Botto· 2 shared A. Cox· 1 shared A. Figueroa· 1 shared A. H. Karaba· 1 shared A. H. Pham· 1 shared A. Raper· 1 shared A. Wickenhagen· 1 shared D. McCormick· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

S. Botto

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3 papers

Recent·Most cited

Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons

A. H. Pham, J. Mitchell, S. Botto, K. M. Pryke, V. R. Defilippis, M. Hancock

This paper shows HCMV miR-UL22A downregulates SMAD3 to block TGFβ signaling and limit type I IFN induction during lytic infection.

bioRxiv · Feb 16, 2021Microbiology

Herpes Simplex Virus type 1 Inflammasome Activation in Human Macrophages is Dependent on NLRP3, ASC, and Caspase-1

A. H. Karaba, A. Figueroa, G. Massaccesi, S. Botto, V. R. DeFilippis, A. Cox

This study shows HSV-1 activates inflammasomes in human macrophages via NLRP3, ASC, and caspase-1, but not AIM2 or IFI16, and the virus inhibits inflammasome activation through an NLRP3-specific mechanism.

PLOS ONE · Feb 26, 2020Peer-reviewedMicrobiology

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early genes.

Y.-T. Lin, S. Chiweshe, D. McCormick, A. Raper, A. Wickenhagen, V. R. DeFilippis, E. Gaunt, P. Simmonds, S. J. Wilson, F. Grey

This study shows HCMV evades ZAP detection by suppressing CpG dinucleotides in its IE1 gene, and TRIM25 regulates ZAP isoform expression.

bioRxiv · Jan 7, 2020Microbiology