Multi-scale predictive modeling discovers Ibudilast as a polypharmacological agent to improve hippocampal dependent spatial learning and memory and mitigate plaque and tangle pathology in a transgenic rat model of Alzheimer's disease
G. Oliveros, C. H. Wallace, O. Chaudry, Q. Liu, Y. Qiu, L. Xie, P. Rockwell, M. Figueiredo-Pereira, P. A. Serrano
The paper uses multi-scale predictive modeling to identify ibudilast as a potential therapeutic for Alzheimer's disease by improving cognition and reducing pathology in a transgenic rat model.
bioRxiv · Apr 6, 2021 · PreprintPharmacology & Toxicology