Pharmacology & ToxicologybioRxivPreprint
Multi-scale predictive modeling discovers Ibudilast as a polypharmacological agent to improve hippocampal dependent spatial learning and memory and mitigate plaque and tangle pathology in a transgenic rat model of Alzheimer's disease
G. Oliveros, C. H. Wallace, O. Chaudry…·P. A. Serrano
The paper uses multi-scale predictive modeling to identify ibudilast as a potential therapeutic for Alzheimer's disease by improving cognition and reducing pathology in a transgenic rat model.
DOI 10.1101/2021.04.06.438662