A Ca2+-regulated deAMPylation switch in bacterial and human FIC proteins.
S. Veyron, G. Oliva, M. Rolando, C. Buchrieser, G. Peyroche, J. Cherfils
This study identifies Ca2+ as a diffusible signal that modulates AMPylation and deAMPylation activities in FIC proteins by controlling a conserved glutamate's role in metal-dependent enzyme function.
bioRxiv · Aug 3, 2018Biochemistry