Author

G. Oliva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 4 Organism:virus· 3 Research Focus:host-pathogen & immune response· 2 Assay:protein structure· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. S. Godoy· 3 shared G. D. Noske· 3 shared R. S. Fernandes· 3 shared A. C. Puhl· 2 shared A. S. de Godoy· 2 shared D. FearoniD· 2 shared F. von DelftiD· 2 shared M. FairheadiD· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

A. S. Godoy

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

A. S. Godoy, N. C. M. R. Mesquita, C. Giroud, G. D. Noske, V. O. Gawriljuk, R. M. Lithgo, B. H. Balcomb, J. C. Aschenbrenner, C. W. E. Tomlinson, M. Winokan, J. Scheen, H. MacDermott-Opeskin, P. G. Marples, A. V. Chandran, X. Ni, , F. von Delft

This study uses high-throughput crystallographic fragment screening to identify 46 fragment binding poses on ZIKV NS3Hel, providing templates for antiviral drug design.

bioRxiv · Apr 27, 2024 · PreprintBiophysics

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease

A. Schutzer Godoy, A. Minalli Nakamura, A. Douangamath, Y. Song, G. Dias Noske, V. Oliveira Gawriljuk, R. Sachetto Fernandes, H. D. Muniz Pereira, K. Irene Zagato Oliveira, D. Fearon, A. Dias, T. Krojer, M. Fairhead, A. Powell, L. Dunnet, , G. Oliva

This study characterizes SARS-CoV-2 NSP15 endoribonuclease, identifies its allosteric properties, and discovers new allosteric sites for inhibitor development.

Nucleic Acids Research · Apr 28, 2023Peer-reviewedBiochemistry

Structural basis of nirmatrelvir and ensitrelvir resistance profiles against SARS-CoV-2 Main Protease naturally occurring polymorphisms

G. D. Noske, E. S. Silva, M. O. Godoy, I. Dolci, R. S. Fernandes, R. V. C. Guido, P. Sjo, G. Oliva, A. S. Godoy

The paper characterizes natural polymorphisms in SARS-CoV-2 main protease and their resistance profiles against nirmatrelvir and ensitrelvir, revealing structural bases for resistance.

bioRxiv · Aug 31, 2022 · PreprintBiochemistry

Discovery of a Novel Inhibitor for Chikungunya Virus

A. C. Puhl, R. S. Fernandes, A. S. Godoy, L. H. V. G. Gil, G. Oliva, S. Ekins

This study identifies 3-methyltoxoflavin as an inhibitor of Chikungunya virus with EC50 200 nM and activity against yellow fever virus.

bioRxiv · Mar 23, 2022 · PreprintMicrobiology

Pyronaridine Protects Against SARS-CoV-2 in Mouse

A. C. Puhl, G. F. Gomes, S. Damasceno, A. S. de Godoy, G. D. Noske, A. M. Nakamura, V. O. Gawrijuk, R. S. Fernandes, N. Monakhova, O. Riabova, T. R. Lane, V. Makarov, F. P. Veras, S. S. Batah, A. T. Fabro, , S. Ekins

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.

bioRxiv · Sep 30, 2021 · PreprintPharmacology & Toxicology

A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process

G. Noske, A. Nakamura, V. Gawriljuk, R. Fernandes, G. Lima, H. Rosa, H. Pereira, A. Zeri, A. Nascimento, M. Freire, G. Oliva, A. S. de Godoy

This paper presents a crystal structure of an immature SARS-CoV-2 main protease, revealing conformational changes that hinder dimerization and activity, and identifies potential therapeutic targets.

bioRxiv · Dec 23, 2020Biochemistry

A Ca2+-regulated deAMPylation switch in bacterial and human FIC proteins.

S. Veyron, G. Oliva, M. Rolando, C. Buchrieser, G. Peyroche, J. Cherfils

This study identifies Ca2+ as a diffusible signal that modulates AMPylation and deAMPylation activities in FIC proteins by controlling a conserved glutamate's role in metal-dependent enzyme function.

bioRxiv · Aug 3, 2018Biochemistry