G. Q. Daley

The paper presents an in vitro model of bone marrow adipocyte subtypes and validates a lipid unsaturation ratio as a marker distinguishing regulated and constitutive adipocytes in both the model and human samples.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

The paper uses single-cell transcriptomics to show that leukemia initiating cells can convert between states, with MYC-driven oxidative phosphorylation controlling this plasticity.