Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death
J. Riley, G. Quarato, J. Lopez, J. O'Prey, M. Pearson, J. Chapman, H. Sesaki, L. Carlin, J. Passos, A. Wheeler, A. Oberst, K. Ryan, S. Tait
This study shows that BAX/BAK-mediated mitochondrial outer membrane pores widen after MOMP, leading to inner membrane permeabilisation and mtDNA release, which triggers inflammation via cGAS-STING.
bioRxiv · Feb 26, 2018Cell Biology