Author

H. Sesaki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Coleman· 1 shared A. Oberst· 1 shared A. Wheeler· 1 shared D. F. Kashatus· 1 shared D. Murata· 1 shared D. T. Sessions· 1 shared G. Quarato· 1 shared J. A. Collins· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCell Biology

A. Coleman

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4 papers

Recent·Most cited

OPA1 protects intervertebral disc and knee joint health in aged mice by maintaining the structure and metabolic functions of mitochondria

V. Madhu, M. Hernandez-Meadows, A. Coleman, K. Sao, K. Inguito, O. Haslam, P. K. Boneski, H. Sesaki, J. A. Collins, M. V. Risbud

This study shows that OPA1 maintains mitochondrial structure and metabolic functions in NP cells and chondrocytes, preventing age-related degeneration in mouse intervertebral discs and knee joints.

bioRxiv · Jan 17, 2024 · PreprintCell Biology

Role of human HSPE1 for OPA1 processing independent of HSPD1

N. Yeung, D. Murata, M. Iijima, H. Sesaki

The paper investigates the role of HSPE1 in OPA1 processing and mitochondrial morphology, finding that HSPE1 depletion leads to OPA1 inactivation via OMA1, independent of HSPD1.

iScience · Feb 1, 2023Peer-reviewedCell Biology

Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma

D. T. Sessions, K.-B. Kim, J. A. Kashatus, N. Churchill, K.-S. Park, M. W. Mayo, H. Sesaki, D. F. Kashatus

This study shows that Opa1, not Drp1, is critical for maintaining ETC function and NAD+ regeneration in KRas-mutant lung adenocarcinoma, with Opa1 deletion inhibiting tumor growth.

bioRxiv · Jun 1, 2022Cell Biology

Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death

J. Riley, G. Quarato, J. Lopez, J. O'Prey, M. Pearson, J. Chapman, H. Sesaki, L. Carlin, J. Passos, A. Wheeler, A. Oberst, K. Ryan, S. Tait

This study shows that BAX/BAK-mediated mitochondrial outer membrane pores widen after MOMP, leading to inner membrane permeabilisation and mtDNA release, which triggers inflammation via cGAS-STING.

bioRxiv · Feb 26, 2018Cell Biology