N-terminal mutants of human apolipoprotein A-I: structural perturbations associated to protein misfolding
G. M. Gaddi, R. A. Gisonno, S. A. Rosu, L. M. Curto, E. E. Elias, E. D. Prieto, G. R. Schinella, G. S. Finarelli, M. F. Cortez, N. A. Ramella, M. A. Tricerri
This study investigates how the L60R mutation in apolipoprotein A-I causes structural instability and misfolding, leading to protein aggregation and inflammatory responses.
bioRxiv · Jan 14, 2019 · PreprintBiophysics