Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition
W. Sun, X. Zhao, J. Wang, X. Yang, Z. Cheng, S. Liu, J. Wang, G. Sheng, Y. Wang
This study reveals that AcrIIC5 mimics dsDNA to inhibit type II-C Cas9 by blocking PAM recognition, providing insights into its mechanism and evolutionary convergence.
bioRxiv · Jan 17, 2023Biochemistry