L. Song

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

This study establishes a mouse model using GX_P2V(short_3UTR) to evaluate drug and vaccine efficacy against SARS-CoV-2.

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

Expanding the genome information on Bacillales for biosynthetic gene cluster discovery

This study presents 121 new Bacillales genomes, identifies 1,176 biosynthetic gene clusters, and provides open-access data to enhance research on secondary metabolite production.

Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.

This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.

Full resolution HLA and KIR genes annotation for human genome assemblies

The paper introduces Immuannot, a tool for annotating HLA and KIR genes in long-read assemblies, identifying novel alleles and haplotype structures.

Oblique Line Scan Illumination Enables Expansive, Accurate and Sensitive Single Protein Measurements in Solution and in Living Cells

This paper introduces Oblique Line Scan (OLS) illumination to enhance single-molecule tracking in living cells and solution, enabling high-throughput and sensitive protein dynamics measurements.

Climate change impacts dryland multifunctionality: A cascade of precipitation variability to species replacement in multitrophic microbiota

This study examines how precipitation variability impacts soil multifunctionality in drylands through changes in microbial communities, revealing cascading effects on ecosystem function.

Mutation of OsCDS5 confers broad-spectrum disease resistance in rice

This study shows that mutating OsCDS5 in rice enhances resistance to multiple diseases by increasing ROS production and defense gene expression.

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead

This paper introduces CMX990, a potent SARS-CoV-2 3CL protease inhibitor with improved potency and clearance compared to nirmatrelvir, advancing to Phase 1 clinical trials.

The role of neutrophil typing in homeostatic resilience protective model of inflammatory preconditioning

This study investigates the role of IRF4 and IRF5 in neutrophil response during septic peritonitis, showing their involvement in PMN phenotype switching and inflammatory outcomes.

Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity

This study introduces a next-generation immunocytokine, LH05, which shows improved antitumor effects in cold tumors with reduced toxicity compared to wild-type anti-PD-L1/IL-15.

The subacromial bursa is a key regulator of the rotator cuff and a new therapeutic target for improving repair

The paper shows that the subacromial bursa is activated by rotator cuff injury and regulates the paracromal environment to maintain tendon and bone properties, suggesting it should be retained for better healing.

Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

This study shows that SRF and MRTFB differentially regulate actin cytoskeleton in hair cells, with SRF-CNN2 playing a critical role in stereocilia and cuticular plate structure.

Host Gastric Corpus Microenvironment Facilitates Ascaris Suum Larval Hatching And Infection in a Murine Model

This study shows that Ascaris suum larvae hatch in the host stomach, not the small intestine, using gastric acid and AMCase, and demonstrates that inhibiting these factors reduces parasitic burden and lung disease.

CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma

This study shows CD155 blockade with allogeneic NK cell infusion improves survival against osteosarcoma in mice, with benefits mediated through DNAM-1.

Enhanced specificity of Bacillus metataxonomics using a tuf-targeted amplicon sequencing approach

The paper develops tuf-targeted primers for high-throughput amplicon sequencing to accurately classify Bacillus species, outperforming 16S sequencing in both synthetic and natural samples.

A unique cell division protein critical for the assembly of the bacterial divisome

This study identifies Aeg1 as a new essential cell division protein in Acinetobacter baumannii that recruits FtsN to initiate cell division.

Genomic analysis of cultivated infant microbiomes identifies Bifidobacterium 2'-fucosyllactose utilization can be facilitated by co-existing species

The paper shows that Bifidobacterium breve can utilize 2'-fucosyllactose with help from co-existing species like Ruminococcus gnavus in infant microbiomes.

Transcription Factor Dynamics in Cross-Regulation of Plant Hormone Signaling Pathways

The paper constructs a cross-regulation network of plant hormone signaling pathways by analyzing transcription factor activity and dynamic regulatory models in Arabidopsis seedlings.

Broader functions of TIR domains in Arabidopsis immunity

This study identifies SADR1 as a TIR-containing receptor that modulates RNL-driven immune signaling in Arabidopsis, revealing TIR domains' broader roles in immunity beyond EDS1-dependent pathways.

ALiCE: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

This paper introduces ALiCE, a scalable eukaryotic cell-free protein synthesis system capable of producing complex proteins at high yields and demonstrating functional activity and post-translational modifications.

Chromosome-level genome assembly of Torreya grandis provides insights into the origin and evolution of gymnosperm-specific sciadonic acid biosynthesis

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products

This study investigates whether prokaryotic Thoeris TIRs can cross-activate plant TIR-immunity and finds they generate overlapping cADPR isomers but have distinct signaling requirements.

Multiplex CRISPR strategy targeting viral genome for agriculture and clinical use

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

Aridity modulates biogeographic distribution and community assembly of cyanobacterial morphotypes in drylands

This study examines how aridity affects the distribution and community assembly of cyanobacterial morphotypes in drylands, finding that stochastic processes dominate but aridity influences the balance between determinism and stochasticity.

Photoperiod and vernalization alleles and their combinations greatly affected phenological and agronomic traits in bread wheat under autumn and spring sowing conditions

This study examines how VRN-1 and PPD-1 alleles affect wheat phenology and yield under autumn and spring sowing conditions.

The cluster transfer function of AtNEET supports the ferredoxin-thioredoxin network of plant cells

This study shows that AtNEET's cluster transfer function supports the ferredoxin-thioredoxin network and iron mobilization in Arabidopsis through proteomics analysis and inducible expression.

Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

Individually unique, fixed stripe configurations of Octopus chierchiae allow for photo-identification in long-term studies

This study shows that Octopus chierchiae has unique, stable stripe patterns that can be used for photo-identification of individuals over time.