Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis
M. Boutry, A. Pierga, R. Matusiak, J. Branchu, M. Houllegatte, Y. Ibrahim, E. Balse, K. H. El Hachimi, A. Brice, G. Stevanin, F. Darios
This study shows that loss of spatacsin impairs cholesterol trafficking and calcium homeostasis, leading to lysosomal lipid accumulation and altered cellular function.
bioRxiv · Apr 11, 2019Cell Biology