A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol
K. Kasho, G. Stojkovic, C. Velazquez-Ruiz, M. I. Martinez-Jimenez, T. Laurent, A. E. Perez-Rivera, L. Jenninger, L. Blanco, S. Wanrooij
This study identifies an arginine cluster in PolDIP2 that enhances PrimPol's nucleotide binding and DNA synthesis by increasing its primer-template and dNTP affinity.
bioRxiv · May 18, 2020Biochemistry