Author

S. Wanrooij

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:DNA methylation· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. Chorell· 3 shared M. Doimo· 3 shared A. Berner· 2 shared M. Andreasson· 2 shared R. N. Das· 2 shared A. Abrahamsson· 1 shared A. E. Perez-Rivera· 1 shared B. Prasad· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

E. Chorell

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

G4-Ligand Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures

A. Berner, R. N. Das, N. Bhuma, J. Golebiewska, A. Abrahamsson, M. Andreasson, N. Chaudhari, M. Doimo, P. P. Bose, K. Chand, R. Stromberg, S. Wanrooij, E. Chorell

The paper develops a method to selectively target and stabilize individual G4 DNA structures using ligand-conjugated oligonucleotides, demonstrating specificity without affecting off-target G4 formations.

bioRxiv · Sep 20, 2023 · PreprintBiochemistry

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells

M. Doimo, S. Abrahamsson, V. L'Hote, M. Ndi, R. N. Das, K. Aasumets, A. Berner, S. Goffart, J. L. O. Pohjoismäki, M. Davila, E. Chorell, S. Wanrooij

The paper shows that mitochondrial DNA replication stalling increases G-quadruplex formation, which blocks replication forks and leads to mtDNA loss in human cells.

bioRxiv · Jun 8, 2022Cell Biology

Towards customized studies of G-quadruplex DNA structures in live cells

B. Prasad, M. Doimo, M. Andreasson, V. L Hote, E. Chorell, S. Wanrooij

The paper develops a synthetic platform to study G-quadruplex DNA structures in live cells using modified Phen-DC3 compounds with fluorescent and cell-penetrating properties.

bioRxiv · Apr 7, 2021Cell Biology

A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol

K. Kasho, G. Stojkovic, C. Velazquez-Ruiz, M. I. Martinez-Jimenez, T. Laurent, A. E. Perez-Rivera, L. Jenninger, L. Blanco, S. Wanrooij

This study identifies an arginine cluster in PolDIP2 that enhances PrimPol's nucleotide binding and DNA synthesis by increasing its primer-template and dNTP affinity.

bioRxiv · May 18, 2020Biochemistry