Cryo-EM structure of an amyloid fibril from systemic amyloidosis
F. Liberta, S. Loerch, M. Rennegarbe, A. Schierhorn, P. Westermark, G. T. Westermark, N. Grigorieff, M. Fandrich, M. Schmidt
The paper determines the cryo-EM structure of an amyloid fibril from AA amyloidosis, revealing its all-β conformation and identifying the N-terminus as critical for fibril assembly.
bioRxiv · Jun 29, 2018Biophysics