Author

S. Loerch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:clustering· 1

Frequent Co-Authors

N. Grigorieff· 3 shared A. A. Korostelev· 1 shared A. Schierhorn· 1 shared B. A. Lucas· 1 shared C. Bao· 1 shared C. F. Halpern· 1 shared C. L. Kielkopf· 1 shared C. Ling· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiophysics

N. Grigorieff

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Author profile →

5 papers

Recent·Most cited

In situ single particle classification reveals distinct 60S maturation intermediates in cells

B. A. Lucas, K. Zhang, S. Loerch, N. Grigorieff

The paper uses 2DTM to classify 60S ribosome maturation intermediates in yeast cells by analyzing their signal-to-noise ratios in cryo-EM micrographs.

bioRxiv · Apr 10, 2022Biophysics

A UHM - ULM interface contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

J. Galardi, V. N. Bela, N. Jeffery, X. He, E. Glasser, S. Loerch, J. L. Jenkins, M. J. Pulvino, P. L. Boutz, C. L. Kielkopf

This study determines the crystal structure of the U2AF2 UHM-SF3B1 ULM interface and shows its role in pre-mRNA splicing and co-regulation with SF1.

bioRxiv · Jan 9, 2022Biochemistry

Small-molecule ligands can inhibit -1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses

S. Munshi, K. Neupane, S. M. Ileperuma, M. T. Halma, J. A. Kelly, C. F. Halpern, J. D. Dinman, S. Loerch, M. T. Woodside

The paper tests small-molecule ligands against -1 PRF in coronaviruses, finding nafamostat inhibits frameshifting in multiple bat CoVs and SARS-CoV-2 but not other viruses.

bioRxiv · Aug 6, 2021 · PreprintBiochemistry

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

C. Bao, S. Loerch, C. Ling, A. A. Korostelev, N. Grigorieff, D. Ermolenko

The paper investigates how mRNA stem-loops impede ribosome movement by hindering A-site tRNA binding and rotation during translation elongation.

bioRxiv · Feb 5, 2020Biochemistry

Cryo-EM structure of an amyloid fibril from systemic amyloidosis

F. Liberta, S. Loerch, M. Rennegarbe, A. Schierhorn, P. Westermark, G. T. Westermark, N. Grigorieff, M. Fandrich, M. Schmidt

The paper determines the cryo-EM structure of an amyloid fibril from AA amyloidosis, revealing its all-β conformation and identifying the N-terminus as critical for fibril assembly.

bioRxiv · Jun 29, 2018Biophysics