G. Timinszky

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

This study shows that loss of POLE4 leads to PARP inhibitor sensitivity independent of BRCA1, through replication stress and DNA-PK signaling changes.

HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage