S. Huet

DNA damage-induced PARP/ALC1 activation leads to Epithelial-to-Mesenchymal transition stimulating homologous recombination.

This study shows DNA damage activates PARP and ALC1 to induce EMT, which enhances DNA repair via RAD51, and PARP inhibitors block this process.

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

This study shows that loss of POLE4 leads to PARP inhibitor sensitivity independent of BRCA1, through replication stress and DNA-PK signaling changes.

Functional precision oncology for follicular lymphoma with patient-derived xenograft in avian embryos

This study develops a xenograft model in avian embryos to study follicular lymphoma response to RCHOP therapy, identifying a gene signature and validating BAX as a key effector of treatment.

Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA scanning and recruitment to oxidized bases in living cells

HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage

A new hypothesis-testing model for phyllochron based on a stochastic process - application to analysis of genetic and environment effects in maize

The paper introduces a stochastic process model for phyllochron analysis in maize, showing differences are mainly due to ancestral lines, years, and leaf ranks rather than selection populations.

The RNA export factor Mex67 functions as a mobile nucleoporin

This study shows Mex67 functions as a mobile nucleoporin in yeast, interacting with the NPC rather than mRNA, and its essential role is spatially restricted to the NPC.

Correlative live and super-resolution imaging reveals the dynamic structure of replication domains

The paper uses correlative live and super-resolution microscopy to study replication domain structure and dynamics in higher eukaryotes, finding RDs are 150 nm in size with specific spacing and mechanical coupling.