Interferon-responsive genes are targeted during the establishment of human cytomegalovirus latency
E. G. Elder, B. A. Krishna, J. Williamson, E. Y. Lim, E. Poole, G. X. Sedikides, C. M. O'Connor, M. Wills, P. J. Lehner, J. Sinclair
This study identifies that US28 downregulates interferon-inducible genes during HCMV latency, with IFI16 suppression enhancing viral gene expression via NF-κB.
bioRxiv · Oct 4, 2019Microbiology