Author

E. Y. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3

Frequent Co-Authors

E. G. Elder· 2 shared M. Wills· 2 shared B. A. Krishna· 1 shared C. J. Houldcroft· 1 shared C. M. O'Connor· 1 shared E. Poole· 1 shared G. Okecha· 1 shared G. X. Sedikides· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

E. G. Elder

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Author profile →

3 papers

Recent·Most cited

Antiviral activity of Cytomegalovirus-specific CD4+ T cells against lytically infected non-haemopoietic cells

E. Y. Lim, C. J. Houldcroft, S. E. Jackson, G. Okecha, M. R. Wills

This study demonstrates that HCMV-specific CD4+ T cells can prevent viral dissemination in fibroblasts and that IFN-γ is a key antiviral cytokine in their secretome.

bioRxiv · Dec 8, 2022 · PreprintImmunology

Targeting the latent human cytomegalovirus reservoir with virus specific nanobodies

T. W. M. De Groof, E. G. Elder, R. Heukers, E. Y. Lim, M. Wills, J. H. Sinclair, M. J. Smit

This study develops a nanobody that partially inhibits HCMV receptor signaling and enhances T-cell killing of latently infected monocytes, offering a potential therapy for clearing HCMV reservoirs in transplant patients.

Nature Communications · Jul 21, 2021Peer-reviewedMicrobiology

Interferon-responsive genes are targeted during the establishment of human cytomegalovirus latency

E. G. Elder, B. A. Krishna, J. Williamson, E. Y. Lim, E. Poole, G. X. Sedikides, C. M. O'Connor, M. Wills, P. J. Lehner, J. Sinclair

This study identifies that US28 downregulates interferon-inducible genes during HCMV latency, with IFI16 suppression enhancing viral gene expression via NF-κB.

bioRxiv · Oct 4, 2019Microbiology