The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death
S. Castro-Obregon, G. Zarraga, G. Mucino-Hernandez, M. R. Sanchez-Carbente, W. Villamizar-Galvez, A. Penas-Rincon, C. Arredondo, M. E. Andres, C. Wood, L. Covarrubias
This study shows SUMOylation of NR4A1 regulates its transcriptional activity, intracellular localization, and is required for inducing autophagic cell death.
bioRxiv · Aug 22, 2019Biochemistry