C. Wood

The python-derived 16α-hydroxylated bile acid, pythocholic acid decreases food intake and increases jejunal fatty acid ethanolamides in mice.

This paper isolates pythocholic acid from ball pythons and shows it reduces food intake and increases jejunal fatty acid ethanolamides in mice, unlike deoxycholic acid.

ADOLESCENT EXPOSURE TO LOW-DOSE THC DISRUPTS ENERGY BALANCE AND ADIPOSE ORGAN HOMEOSTASIS IN ADULTHOOD

This study shows that adolescent exposure to low-dose THC leads to metabolic changes in adulthood, including reduced fat mass and adipose dysfunction.

Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data

The paper shows that transcriptional signatures in tumour samples can be misinterpreted due to stromal influences, affecting alignment with preclinical data.

Opposing dominance within a color gene block is associated with maladaptive hybrid signal discordance

The study examines how opposing genetic dominance in a color gene block affects plumage signals and territorial behavior in hybrid songbirds, linking genetic variation to fitness outcomes.

Image3C: a multimodal image-based and label independent integrative method for single-cell analysis

Image3C enables single-cell analysis without species-specific reagents by using image-based clustering and CNN integration to detect cellular composition changes.

The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

This study shows that the wtf4 meiotic driver uses protein aggregation and sequestration to selectively kill cells, revealing a mechanism for meiotic drive.

Sperm chemotaxis is driven by the slope of the chemoattractant concentration field

This study shows that sea urchin sperm chemotaxis depends on the slope of chemoattractant concentration gradients, mediated by coupling two oscillators: the stimulus function and intracellular calcium changes.

The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death

This study shows SUMOylation of NR4A1 regulates its transcriptional activity, intracellular localization, and is required for inducing autophagic cell death.

Cryptic and extensive hybridization between ancient lineages of American crows

This study uses genomic data to show extensive hybridization between Northwestern and American crows, with distinct evolutionary histories and a broad hybrid zone.

Nanoscale organization of rotavirus replication machineries

This study uses super-resolution microscopy to reveal the nanoscale organization of rotavirus replication machineries, showing seven viral proteins and dsRNA arranged in six concentric layers within viro-plasms.

SOCIAL STRESS AS A PRIMING MECHANISM FOR THERMAL TOLERANCE DURING A POLEWARD RANGE SHIFT

This study investigates how social factors and climate influence cold tolerance in range-shifting damselflies, finding that social interactions affect thermal acclimation and range margins.

Conserved Roles of C. elegans and Human MANFs in Sulfatide Binding and Cytoprotection

This study identifies C. elegans MANF orthologue, shows it binds sulfatide, and demonstrates sulfatide-dependent cytoprotection in both worms and mammalian cells.

Geographically structured genetic variation in the Medicago lupulina-Ensifer mutualism

The paper examines genetic variation in the Medicago lupulina-Ensifer mutualism across North America, finding geographically structured coevolution between the plant and the Ensifer genus but not between the plant and individual Ensifer species.

No evidence for adaptation to local rhizobial mutualists in the legume Medicago lupulina

This study tests if Medicago lupulina adapts to local rhizobial mutualists and finds no evidence of adaptation despite geographic variation in rhizobium species.